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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Immunol. 2012 Apr 2;188(9):4278–4288. doi: 10.4049/jimmunol.1101291

FIGURE 4.

FIGURE 4

TB granulomas in IL-2–treated group were less necrotic than those in controls. Histopathology analyses show that control macaques exhibited widespread necrosis, fulminant TB pneumonia, and TB hemorrhage/thrombosis lesions. The alveolar septa are destroyed or indistinct. In contrast, most TB granulomas in lung sections of the IL-2–treated group were well contained and lymphocytic (note the lymphocyte cuff), without widespread necrosis. Original magnification ×100 for all photos. Similar contrasting data were also seen in other controls and IL-2–treated macaques, respectively.