Table 2.

Summary of individuals with neurofibromatosos type 1 and pathologically confirmed glomus tumors. CRPS : complex regional pain syndrome Patients NIH-1, NIH-2 and Leu-1 through Leu-7 previously reported in Brems et al 2009. Patients Leu-2 and Leu-3 previously reported in De Smet et al 2002.

Patient number	Gender	Age at diagnosis of glomus tumor (yrs)	Estimated neurofibroma burden at first glomus tumor evaluation	No. of café-aulait macules (1.5 cm+)	No. years glomus tumor symptoms at presentation	No. painful finger(s)/toes	No. fingers/toes surgically explored (grouped by surgery)	No. histologically confirmed glomus tumors	Comments
NIH-1	F	35	11–50	10	5	6	3+4+3	4:Left F4 (2 synchronous tumors), F5; Right F3	3 surgeries, recurrence in 1 digit, CRPS. See Figure 1.
NIH-2	M	50	1–10	17	20	6	3+4+3	7: Left F2 (twice), F4 (twice); Right F1 (twice), F4	3 surgeries, recurrence in 3 digits, CRPS. See Figure S1.
NIH-3	F	28	101–500	16	4	3	3	1: Left F3	CRPS. See Figure S2.
NIH-4	F	49	1–10	14	40+	1	1	1: Left F3	See Figure S3.
NIH-5	F	35	Unknown	17	18	1	1	1: Left F3	Surgery at another institution at age 35. No recurrence
Leu-1	F	42	11–50	Unknown	1–2	2	2	2: right F4 and right F5	1 surgery, no recurrence
Leu-2	M	35	51–100	Unknown	2–3	2	2	2: right F3 and right F4	1 surgery, no recurrence
Leu-3	F	52	11–50	Unknown	1	2 +1	2+1	2: left F3 and right F4; 2: Left F4	2 surgeries with 6 year interval, no recurrence in same finger. See Figure 2
Leu-4	M	57	101–500	Unknown	5+	1	1	1: right F4	1 surgery, no recurrence. See Figure 2
Leu-5	F	41	11–50	Unknown	4	1	1	1+1: left F3	2 surgeries with 13 months interval (recurrence at same location) See Figure 2
Leu-6	F	46	11–50	3	1–2	1	1	1: right F3	1 surgery, no recurrence, mosaic NF1
Leu-7	F	11	0	Unknown	2–3	1	1	1: left F5	Mild shortening of left fifth finger, large tumor, 1 surgery no recurrence. See Figure 3.
Leu-8	F	34	100–500	Unknown	4	1	1	1: left F4	1 surgery, short follow-up. See Figure 2
Hamburg-1	F	25	20	10	5	2	1+1	1: left F4
Hamburg-2	F	57	450	12	1	1	1	1: right T1