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. Author manuscript; available in PMC: 2012 Aug 6.
Published in final edited form as: J Med Genet. 2010 Jun 7;47(8):525–532. doi: 10.1136/jmg.2009.073965

Table 3.

Summary of demographic and physical features of pathologically-proven sporadic and neurofibromatosis type 1-associated glomus tumors of the fingers and toes. Data on patients Leu-2 and Leu-3 excluded from "Combined NIH/Belgian/Hamburg experience" since they were previously reported[2] and thus accounted in "Previously reported NF1-associated glomus tumors." Includes data on NIH-5. Data on "Previously reported NF1-associated glomus tumors" from references listed in Table 1. Data on sporadic glomus tumors from van Geertruyden et al 1996 and Vasisht et al 2004.

Feature Combined NIH/Belgian/Hamburg
experience in pathologically proven
glomus tumors
Previously reported NF1-
associated glomus tumors
(pathologically-proven)
Sporadic glomus tumors (data combined from van Geertruyden et al 1996 and Vasisht et al 2004)
Male:Female 2 M (15%); 11 F (85%) 2 M (29%); 5 F (71%) 11 M (16%); 59 F (84%)
Right:Left (Fingers and toes) Right: 42%; Left: 58% Right: 41%; Left: 59% van Geertruyden: Right: 47%; Left: 53%; Vasisht: Right: 57%, Left: 42%
Location of tumor
Thumb (F1) 1 (5%) 2 (10%) 17 (24%)
F2 1 (5%) 3 (14%) 8 (11%)
F3 6 (32%) 5 (24%) 18 (26%)
F4 8 (42%) 7 (33%) 18 (26%)
F5 3 (16%) 4 (19%) 9 (13%)
Finger Totals 19 (100%) 21 (100%) 70 (1005)
Toes 1 1 0
Patients with multi-focal tumors 3/15 (20%) 5/6 (83%) None
Years of symptoms prior to diagnosis 1 to 40+ years Up to 20 years 1 to 40 years
Average age of diagnosis (yrs) 40 (combined, range 11–57); 54 (M, range: 50–57); 38 (F, range 11–57) 33 (combined, range 17 – 53); 40 years (M, range: 35–45); 31 years (F, range: 17–53) van Geertruyden: 44 (combined, range 26–83); Vasisht: 43 (combined, range: 14–95); 40 (M, range: 28–72); 43 (F, range: 14–95)