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Cell-permeable p18INK4c suppresses the growth of larger tumors. (a,b) Suppression of tumors induced by subcutaneous injection of (a) HCT116 tumor cells or (b) HCT116 tumor explants. After tumors reached a size of ~120 mm3 (start), the mice were injected daily (i.v.) for 3 weeks with diluent alone (black) or with 300 µg Hp18 (blue), HM103p18 (red) or HM103E (green).
