. Author manuscript; available in PMC: 2012 Aug 6.

Published in final edited form as: J Allergy Clin Immunol. 2009 Dec 29;125(2 Suppl 2):S297–S305. doi: 10.1016/j.jaci.2009.08.043

Table VII. Differential diagnosis of phagocyte defects and associated laboratory findings.

Chronic granulomatous disease: defective oxidative burst by means of DHR assay or NBT

Leukocyte adhesion defects

LAD1: low/absent CD18 and CD11 expression by means of flow cytometry; persistent leukocytosis

LAD2: Bombay phenotype; absent CD15 (Sialyl-Lewis X) expression

LAD3: mutation analysis only

Chediak-Higashi syndrome: giant lysosomal inclusion bodies observed on morphologic review of granulocytes (with partial albinism)

Griscelli syndrome type 2: neutropenia without inclusion bodies (with partial albinism)

Severe congenital neutropenia: persistent neutropenia; maturation arrest on bone marrow studies

Cyclic neutropenia: intermittent neutropenia requiring serial measurements

X-linked neutropenia: altered WASP expression by means of flow or mutation analysis

G6PD and MPO deficiency: abnormal functional enzymatic assay

Hyper-IgE syndrome: IgE level >2,000 IU/mL; low T_H17 cell numbers

Other disorders to be considered

Drug-induced neutropenia; autoimmune/alloimmune neutropenia; hypersplenism; chronic mucocutaneous candidiasis; TCII deficiency; hyper-IgM syndrome, XLA; Schwachman-Bodian-Diamond syndrome; warts, hypogammaglobulinemia, immunodeficiency and myelokathexis (WHIM) syndrome

NBT, Nitroblue tetrazolium; WASP, Wiskott-Aldrich syndrome protein; G6PD, glucose-6-phosphate dehydrogenase; MPO, myeloperoxidase; XLA, X-linked agammaglobulinemia.