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. Author manuscript; available in PMC: 2012 Aug 6.
Published in final edited form as: Nat Genet. 2011 Mar 13;43(4):321–327. doi: 10.1038/ng.787

Figure 4. Differences in the distributions of protective alleles by ethnicity.

Figure 4

(a) Distributions of protective alleles by ethnicity and case-control status. Numbers of protective alleles were scored for the combined Asian (N=3,556) and European (N=2,410) cohorts. Europeans harbor much greater numbers of protective alleles. The differences in the distribution of protective alleles between Asians and Europeans are highly significant within both case and control groups (Chi-square p=4.9 × 10−72 and p=6.4 × 10−60 for cases and controls, respectively). (b) Distributions of protective alleles among the three HapMap populations: there were highly significant differences between Asian (CHB+JPT) vs. Europeans (CEU, p=1.3×10−3) and Asian vs. Yorubans (YRI, p=7.1×10−6) populations.