Table IX.
Dose reduction and treatment discontinuation due to toxicity in patients older and younger than 65 years of agea.
| Patient age | ||
|---|---|---|
|
|
||
| <65 years (n=52) | ≥65 years (n=44) | |
| Capecitabine | ||
| Dose reduction | 18 (35%) | 18 (41%) |
| Median time to dose reduction | 76 days | 90 days |
| Oxaliplatin | ||
| Dose reduction | 17 (33%) | 17 (39%) |
| Median time to dose reduction | 106 days | 90 days |
| Treatment discontinuation due to toxicity | 10 (19%) | 6 (14%) |
| Death | 0 | 3 (7%)b |
a
Based on the findings of Twelves et al (12).
b
Only one case was treatment-related.