Table I.
Clinical characteristics of the enrolled patients.
| Characteristics | Untreated control | VK + ACE-I | P-value |
|---|---|---|---|
| No. of patients | 28 | 26 | |
| Age (range; years) | 61.4±10.3a | 62.5±9.6 | 0.363b |
| Gender (M/F) | 18/10 | 19/7 | 0.491c |
| Etiology (HCV/HBV/other) | 24/3/1 | 22/3/1 | 0.911c |
| Alcohol (<40 g/>40 g/day) | 16/12 | 13/13 | 0.602c |
| Tumor stage (I/II/III) | 15/11/2 | 13/12/1 | 0.898c |
| Tumor mean size (mm) | 21.2±8.7 | 18.9±9.1 | 0.412b |
| No. of tumors | 1.76±1.12 | 1.55±0.83 | 0.068b |
| AFP (ng/ml) | 76.5±213.3 | 83.3±262.5 | 0.150b |
| PIVKA-II (mAU/ml) | 52.3±60.8 | 60.5±72.6 | 0.188b |
| ALT (IU/l) | 71.4±33.5 | 72.3±36.6 | 0.329b |
| Child-Pugh score (A/B) | 23/5 | 21/5 | 0.897c |
a
Data represents mean ± SD.
b, c
Statistical analysis was performed with the Mann-Whitney U and Fisher’s exact probability tests, respectively.
AFP, α-fetoprotein; PIVKA-II, des-γ-carboxyprothrombin and ALT, alanine aminotransferase.