Table I.

Compound 8 activity against the colon cancer HT-29 cell line in vivo.

	Tumor volume/mouse Day
	11	13	17	20	25	27
Controls (17)	85.9 mm3	240.8 mm3	285.8 mm3	404.1 mm3	450.0 mm3	8/17
13 (10) 35 mg/kg a.m. 25 mg/kg p.m i.p. x 5	50.1 mm3	91.4 mm3	129.3 mm3	204.0 mm3	276.0 mm3	1/10
13 (5) 35 mg/kg a.m. i.p. x 5 10 mg/kg 6 h later i.p. x 5 15 mg/kg 12 h later i.p. x 5	43.2 mm3	92.0 mm3	97.7 mm3	201.3 mm3	216.6 mm3	1/5

Tumor-bearing mice were sacrificed when their tumors reached an estimated 1 cm³. Measurements were in 2 dimensions, and tumor volume was calculated by the formula: TV= (LxW) 2/2. Numbers in parentheses indicate the effective no. of mice. The no. of mice sacrificed when the tumors reached 1 cm³ over the effective number of mice at 27 days is shown. i.p., intraperitoneally.