Table 6.

AUC for diagnosis of prostate cancer based on total PSA, free PSA, %free PSA and hK2 at age 44–50, overall and for men with total PSA above the median and above the upper quartile. 95% confidence intervals are given in parentheses.

Model	Any cancer	Palpable cancer	Advanced cancer
All
Number of cases/controls	998/2811	588/1627	309/855
Total PSA	0.722 (0.704, 0.740)	0.735 (0.709, 0.758)	0.759 (0.725, 0.790)
Free PSA	0.673 (0.655, 0.693)	0.688 (0.663, 0.712)	0.725 (0.690, 0.757)
% Free PSA	0.658 (0.641, 0.674)	0.673 (0.650, 0.693)	0.665 (0.634, 0.695)
hK2	0.630 (0.612, 0.652)	0.644 (0.620, 0.672)	0.660 (0.627, 0.697)
Combination	0.728 (0.711, 0.746)	0.741 (0.718, 0.764)	0.759 (0.727, 0.791)
Above the median (≥ 0.63 ng/ml)
Number of cases/controls	784/1366	465/776	251/413
Total PSA	0.657 (0.633, 0.684)	0.675 (0.648, 0.713)	0.711 (0.673, 0.758)
Free PSA	0.590 (0.569, 0.617)	0.609 (0.586, 0.651)	0.661 (0.628, 0.716)
% Free PSA	0.618 (0.595, 0.639)	0.636 (0.603, 0.663)	0.630 (0.575, 0.658)
hK2	0.580 (0.557, 0.608)	0.600 (0.568, 0.637)	0.610 (0.580, 0.666)
Combination	0.672 (0.650, 0.697)	0.695 (0.667, 0.729)	0.715 (0.680, 0.766)
Above the top quartile (≥ 0.95 ng/ml)
Number of cases/controls	552/663	333/377	196/204
Total PSA	0.618 (0.573, 0.648)	0.653 (0.601, 0.699)	0.671 (0.605, 0.732)
Free PSA	0.547 (0.510, 0.584)	0.583 (0.532, 0.629)	0.620 (0.560, 0.688)
% Free PSA	0.605 (0.562, 0.629)	0.623 (0.581, 0.667)	0.602 (0.547, 0.652)
hK2	0.600 (0.575, 0.646)	0.619 (0.577, 0.674)	0.630 (0.564, 0.698)
Combination	0.659 (0.628, 0.695)	0.687 (0.651, 0.745)	0.705 (0.644, 0.769)