. Author manuscript; available in PMC: 2013 Jul 27.

Published in final edited form as: J Nat Prod. 2012 Jul 3;75(7):1383–1392. doi: 10.1021/np300316b

Table 5.

Cytotoxic activity of the new angucyclines 1–6, compared to the previously known saquayamycins A (7) and B (8) and with the angucyclin lead compound landomycin A^37–39 (GI₅₀ values, μM).

No.	Name and Structure	PC3 cells - 48hr		H460 cells - 48hr
No.	Name and Structure	GI₅₀ (μM)	95% Confidence Intervals	GI₅₀ (μM)	95% Confidence Intervals
1:	Saquayamycin G (R¹ = I, R² = X)	0.5535	0.4879 – 0.6280	6.718	4.771 – 9.459
2:	Saquayamycin H (R¹ = II, R² = XI)	0.7898	0.7354 – 0.8482	3.302	2.102 – 5.188
3:	Saquayamycin I (R¹ = III, R² = X)	0.9149	0.8087 – 1.035	7.943	5.557 – 11.35
4:	Saquayamycin J (R¹ = II, R² = XII)	0.1791	0.1425 – 0.2251	5.694	4.284 – 7.567
5:	Saquayamycin K (R¹ = V, R² = X)	0.1478	0.09491 – 0.2303	7.281	5.519 – 9.605
6:	Saquayamycin B1 (R¹ = II, R² = H)	1.759	0.2774 – 11.16	13.20	7.965 – 21.87
7:	Saquayamycin A (R¹ = IV, R² = X)	0.1057	0.09697 – 0.1153	6.195	4.617 – 8.312
8:	Saquayamycin B (R¹ = II, R² = X)	0.07454	0.06720 – 0.08267	3.929	2.895 – 5.333
-	Landomycin A	0.5505	0.4982 – 0.6081	4.109	2.548 – 6.626