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Schematic diagram of the Ras signaling pathway which is disrupted in juvenile myelomonocytic leukemia (JMML). Inherited susceptibility to JMML genes are depicted in light blue. Genes with somatic mutation in JMML are depicted in pink. The impact of Ras signaling on ASXL1 function is not clear. RTK, receptor tyrosine kinase. Modified with permission from Curr Opin Genet Dev.14
