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Mechanisms of hepatic fibrogenesis and possible molecular serum biomarkers. Some molecular serum biomarkers may reflect the pathogenesis of liver fibrosis: neo-epitopes, are related to basement membrane degradation; pro-collagen, is related to extracellular matrix (ECM) synthesis; MMPs and TIMPs are relate to ECM fibrolytic processes; ALT and AST are related to liver function and injury; other serum markers are fibrogenesis-related cytokines.
