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DNA damage signaling pathway in parental cells and 82FR-31NR cells. Radiation activates the p53 pathway to induce apoptosis in irradiated parental cells. On the other hand, the AKT/cyclin D1/Cdk4 pathway is activated by irradiation in 82FR-31NR cells. The AKT pathway facilitates DNA repair of radiation-induced DNA damage and promotes cell survival in 82FR-31NR cells after irradiation.
