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. 2012 Jun 25;1(6):e14. doi: 10.1038/oncsis.2012.14

Figure 2.

Figure 2

Frequency of copy number loss of 3p clones among ccRCC cases grouped by absence (wild-type) or presence of VHL gene inactivation (through sequence alteration or promoter hypermethylation). Region A (telomere to RP11-180G14): the frequency of copy number loss of individual 3p clones differed significantly between VHL wild-type and inactivated cases that occurred through both sequence alteration (P<0.00001) and promoter hypermethylation (P=0.03–0.001). Region B (from RP11-180G14to RP11-154H23): the frequency of clonal copy number loss differed significantly between wild-type cases and those with sequence alterations (P=0.003–<0.00001), but was no longer observed with hypermethylated cases (P=0.08–0.59).