Table 2. Summary of statistics for phospho-PEA-15 and β-catenin expressiona.

Analysis categories	Tumor n (%)		Normal n (%)	P
	High	Low		Normal vs tumor
Total PEA-15-pS104	48/60 (80.0)	12/60 (20.0)	0/10 (0.0)
Tumor grade
I	10/13	3/13		0.0004
II	20/26	6/26		<0.0001
III	18/21	3/21		<0.0001
Total PEA-15-pS116	36/60 (60.0)	24/60 (40.0)	9/10 (90.0)	0.08
β-catenin	21/60 (35.0)	39/60 (65.0)	5/10 (50.0)	0.48
Double phopshorylation status
PEA-15 high-pS104/low-pS116	17/60 (25.8)		0/10 (0.0)	0.1043
PEA-15 low-pS104/high-pS116	2/60 (3.3)		9/10 (90.0)
Tumor grade
I	0/13			<0.001
II	2/26			<0.001
III	0/21			<0.001
PEA-15 high-pS104/high-pS116	33/60 (55)		0 (0.0)
Tumor grade
I	5/13			0.046
II	15/26			0.002
III	13/21			0.001
PEA-15 low-pS104/low-pS116	8/60 (13.3)		1/10 (10.0)	1

Note: Bonferroni method was used to adjust for multiple comparisons, therefore only P-values <0.05/9=0.0056 was considered statistically significant in the above table. The P-values highlighted in bold are considered significant.

^aSamples are categorized according to their expression of markers (low intensity=0 or 1 and high intensity=2 or 3).