Table 4.

Net improvement on reclassification of individual risk of heart failure using the variables in the basic ARIC risk score and the addition of NT-proBNP

ARIC basic model	ARIC basic model with addition of NT-proBNP
	10-Year Risk
	<5%			5 to <10%			10 to <20%			20% or more			Overall
10-Year Risk	n	row %	Risk	n	row %	Risk	n	row %	Risk	n	row %	Risk	n	%	Risk
<5%	4080	87.55	0.018	528	11.33	0.047	48	1.03	0.219	4	0.09	0.5	4660	46.12	0.023
5 to <10%	919	33.33	0.036	1360	49.33	0.062	433	15.71	0.144	45	1.63	0.362	2757	27.29	0.07
10 to <20%	134	7.9	0.074	528	31.11	0.081	744	43.84	0.146	291	17.15	0.287	1697	16.8	0.142
20% or more	8	0.81	0.25	44	4.45	0.165	231	23.36	0.184	706	71.39	0.424	989	9.79	0.35
Overall	5141	50.89	0.023	2460	24.35	0.065	1456	14.41	0.154	1046	10.35	0.383	10103	100	0.085
NRI	13.5%

ARIC = Atherosclerosis Risk In Communities Study, NRI = Net Reclassification Improvement ; basic refers to model without biomarkers but only variables routinely and available to primary care physicians i.e., age, race, gender, blood pressure, heart rate, history of diabetes and CHD.