Table 1.
Distribution of Selected Characteristics andESR1Polymorphisms in Participants
| Characteristic | ASC |
HBV-ALF |
P value |
|---|---|---|---|
| (n =857) | (n = 359) | ||
| Gender, no. (%) | |||
| Men |
510 (59.5) |
298 (83.0) |
|
| Women |
347 (40.5) |
61(17.0) |
<0.001 |
| Age (years), mean (SD) |
36.6 ± 11.3 |
41.1 ± 12.7 |
<0.001 |
| Alcohol drinkers, no. (%) |
160(18.7) |
121 (33.7) |
<0.001 |
| HBeAg positive, no (%) |
298(34.8) |
107(29.8) |
0.094 |
| TBil (μmol/L) |
13.4 ± 4.3 |
321.1 ± 166.1 |
|
| ALT (IU/L) |
27.9 ± 10.7 |
410.1 ± 541.6 |
|
| c.453-397 T > C (rs2234693) | |||
| TT, no. (%) |
330(38.4) |
109(30.4) |
|
| TC, no. (%) |
424(49.6) |
182(50.7) |
|
| CC, no. (%) |
103(12.0) |
68(18.9) |
|
| T allele, no. (%) |
1086(62.4) |
400 (55.7) |
|
| C allele, no. (%) |
632(36.9) |
318 (44.3) |
5.37 × 10-4 |
| c.30 T > C (rs2077647) | |||
| TT, no. (%) |
418(48.8) |
143 (39.8) |
|
| TC, no. (%) |
348(40.6) |
160 (44.7) |
|
| CC, no. (%) |
91 (10.6) |
56 (15.6) |
|
| T allele, no. (%) |
1184(69.1) |
446 (62.1) |
|
| C allele, no. (%) | 530 (30.9) | 272 (37.9) | 8.65 × 10-4 |
Notes: “Drinker” was defined as alcohol consumption of ≥40 g/week for men and ≥20 g/week for women, which included occasional drinkers and daily drinkers. The genotype distributions of SNPs in each group were in Hardy–Weinberg equilibrium. P values were given for the comparison between ASC and HBV-ALF groups by χ2 tests. TBil, total bilirubin; ASC, asymptomatic HBV carriers; HBV-ALF, patients with HBV-related acute liver failure.