Figure 1.

(a) Crystals of hRack1. (b) Content of the asymmetric unit, with the three different hRack1 molecules coloured cyan, green and purple. (c) Sequence alignment of the Rack1 orthologues for which structures have been reported: hRack1, human (this work); yRack1, yeast; aRack1, Arabidopsis thaliana; tRack1, Tetrahymena thermophila. See text for details. The seven WD domains found in hRack1 are highlighted in different colours. Conserved residues that typically define the primary sequence of WD domains are shown in red for the WD dipeptide, in blue for the GH dipeptide, in green for aspartate residues and in yellow for serine residues.