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. 2012 Aug 6;7(8):e42609. doi: 10.1371/journal.pone.0042609

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© 2012 Wichroski et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. The genome replication inhibitors (Inhs 6–13) were confirmed by comparing potency (EC₅₀) against the 1a/2a-Rluc virus and a corresponding JFH1 replicon. B & C. Genotype 2a and HCV selectivity were assessed by comparing inhibitor potency against genotype 2a, genotype 1a and BVDV replicons and compounds were subsequently grouped into genotype 2a-selective (B) and non-selective (C).