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. 2012 Aug 6;7(8):e42152. doi: 10.1371/journal.pone.0042152

Figure 5. AP-1-mediated recruitment of HDAC1 to MMP-9 promoter in response to IFNβ - a schematic model.

Figure 5

Based on our results and some of the previously published work [18], this model indicates what is occurring at the MMP-9 promoter under IFNβ treatment conditions. (A) Under uninduced conditions, there is a basal level of HDAC1 and general transcription factor occupation of the MMP-9 promoter. (B) Upon PMA treatment, recruitment of specific transcription factors NF-κB, AP-1, and Sp1 occurs and MMP-9 transcription is induced. Coactivators are also recruited, such as p300, which results in acetylation of the lysine tails of histones. (C) IFNβ treatment causes HDAC1 to be recruited to the proximal AP-1 site and a corresponding decrease in local acetylation, leading to decreased transcriptional activation of MMP-9. While AP-1 occupation of the MMP-9 promoter is unchanged under IFNβ treatment, NF-κB and other specific activators leave the promoter.