Table 2. Fibrosis.

Age (months)	6	12	18	24	30	36	42
α-SMAgrading (0–4)	1(−)	2(1–2)	2(2–2.5)	3(2–4)	3(3–4)	4(2–4)	3(2–4)
p-value	−	0.15	0.048	0.057	0.053	0.054	0.057
Reticulingrading (0–3)	0(−)	1(0–1)	0(0–1)	1(0–2.5)	0(0–2.5)	2.5(0–3)	2(1–3)
p-value	−	0.15	1	0.17	0.37	0.17	0.058

Fibrosis scoring: α-SMA (hepatic stellate cell activation) and reticulin grading (collagen type III) in five COMMD1-deficient dogs in a time-dependent copper-induced hepatitis. Data are presented as median (range).

α-SMA grading; 0: no staining of HSCs; 1: a few positive HSCs; 2: diffuse staining of HSCs; 3: mild increased staining of HSCs; 4: marked increased staining of HSC and compared with age matches normal controls.

Reticulin grading; grade 0: normal, grade 1: local mild centrilobular increase, grade 2: multifocal mild to moderate centrilobular increase, grade 3: moderate increase with centro-central bridging or nodular transformation. The uncorrected p-values for comparison of each time point with 6 months of age are reported in the table. No significant differences are present when correcting these p-values for the number of tests.