Table 3. Table 3. Apoptosis and regeneration.

Age (months)	6	12	18	24	30	36	42
Casp3	0(−)	0(−)	0(−)	0(−)	0.1(0–3)	0.1(0–1.1)	0.1(0–0.1)
p-value	−	NA	NA	NA	0.15	0.17	0.35
Ki67	0.9(0.6–2.9)	0.8(0.4–1.1)	1.1(0.7–2.0)	0.5(0.3–1.3)	0.7(0.1–1.0)	2.3(0.1–4.4)	2.1(1–4.6)
p-value	−	0.79	0.88	0.25	0.13	0.88	0.5
K19	1.9(1.2–3.2)	2.5(1–3.3)	3.2(2.7–3.4)	1.8(1.5–3.3)	3.7(2.5–5.3)	3.6(2.8–7.4)	5.2(4–9.6)
p-value	−	0.10	0.063	0.58	0.058	0.063	0.125

NA: not available.

Number of (active) caspase-3 (Casp3) positive hepatocytes per 10-times objective (manual count), number of Ki67 positive hepatocytes per 10-times objective (manual count), and number of K19 positive cells in the limiting plate per portal area in five COMMD1-deficient dogs in a time-dependent copper-induced hepatitis. Data are presented as median (range).

The uncorrected p-values for comparison of each time point with 6 months of age are reported in the table. No significant differences are present when correcting these p-values for the number of tests.