Table 1. Insertion sites in CFCs isolated from young and aged recipient mice.
| In young microenvironment | In old microenvironment | ||||
| Gene ID | Official gene symbol | Gene ID | Official gene symbol | ||
| Endocytosis GO cluster: | Regulation of transcription GO cluster: | ||||
| 20403 | Itsn2 | 14013 | Mecom, Evi1 | ||
| 20910 | Stxbp1 | 17863 | Myb | ||
| 227738 | Lrsam1 | 52915 | Zmiz2 | ||
| Genes with miscellaneous function: | Genes with miscellaneous function: | ||||
| 11534 | Adk | 12857 | Cox4i1 | ||
| 12014 | Bach2/Evi59 * | 17909 | Myo10 | ||
| 12540 | Cdc42 | 19252 | Dusp1 | ||
| 12561 | Cdh4 | 22379 | Fmnl3 | ||
| 14297 | Fxn | 52906 | Ahi1 | ||
| 15403 | Hoxa6 | 54614 | Prpf40b | ||
| 15404 | Hoxa7 | 67561 | Wdr48 | ||
| 16800 | Arhgef2 | 68581 | Tmed 10 | ||
| 17977 | Ncoa1 | 74498 | Gorasp1 | ||
| 18263 | Odc1 | 75740 | Egfem1 | ||
| 21873 | Tjp2 | 110213 | Tmbim6 | ||
| 23984 | Pde10a | 217718 | Nek9 | ||
| 53602 | Hpcal1 | 268373 | Ppi A | ||
| 54169 | Myst4 | Genes with unknown function: | |||
| 56459 | Sae1 | 432939 | Gm5468 | ||
| 57915 | Tbc1d1 | 545510 | Gm10258 | ||
| 71801 | Plekhf2 | 666668 | Gm8225 | ||
| 140858 | Wdr5 | 100417604 | Gm18709 | ||
| 227737 | Fam129b | 100502810 | Gm19388 | ||
| 242093 | Rxfp4 | 100504283 | Gm20149 | ||
| 320150 | ZDHHC17 | ||||
| 330474 | Zc3h4 | ||||
| 381409 | Cdh26 | ||||
| 414084 | Tnip3 | ||||
| 435391 | Dupd1 | ||||
| Genes with unknown function: | |||||
| 66931 | 1700010I14Rik | ||||
| 67791 | 6530411M01Rik | ||||
| 68169 | A930038C07Rik | ||||
| 72628 | 2700086A05Rik | ||||
| 76947 | 2310030N02Rik | ||||
| 432502 | Gm5428 | ||||
| 595140 | Gm6044 | ||||
| 665533 | Gm13004 | ||||
| 100038651 | D130062J21Rik* | ||||
| 100188958 | Gm15824 | ||||
| 100417345 | Gm18548 | ||||
| 100417946 | Gm18913 | ||||
| 100503024 | Gm19512 | ||||
| 100503065 | LOC100503065 | ||||
| 100504144 | Gm13421 | ||||
RISs isolated from CFC mice with a chimerism higher than 15% (also displayed in Figure 2/D, see also Material and Methods S1) are listed. Gene categories were defined by the DAVID gene ontology (GO)21, using high classification stringency option by clustering. For Endocytosis GO group, the Fisher Exact test gave a P-value of 4.0E−2 and for Regulation of transcription GO group P-value = 2.9E−1.
*
= same RISs were found in 2 different young recipient mice (transplanted with two different pools of transduced cells), all the other RISs were unique within the experiments.