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. 2012 Aug 6;7(8):e42295. doi: 10.1371/journal.pone.0042295

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© 2012 Zhou et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The effect of various concentrations of drug on the action potential for A: open state block, and B: closed state block. The degree of block was determined by holding at −70 mV, the applying a test pulse to +50 mV for 500 ms. C: Open state binding of Drug O. D: Closed state binding of Drug C. Change in peak (▪), change in total current flow (○). Solid lines are Boltzmann fits to the data .

Inline graphic — The effect of various concentrations of drug on the action potential for A: open state block, and B: closed state block. The degree of block was determined by holding at −70 mV, the applying a test pulse to +50 mV for 500 ms. C: Open state binding of Drug O. D: Closed state binding of Drug C. Change in peak (▪), change in total current flow (○). Solid lines are Boltzmann fits to the data .