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. Author manuscript; available in PMC: 2013 Aug 3.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Jul 10;424(3):620–623. doi: 10.1016/j.bbrc.2012.06.163

Fig. 2.

Fig. 2

Endoglin down-regulation of c-Myc requires β-arrestin2 interaction. (A) Comparison of c-Myc expression in Eng+/+ and Eng-/- MEECs. (B) Comparison of c-Myc in HMEC-1 in non-targeting control (NTC) versus endoglin knockdown (shEng) after 48 h. (C) c-Myc expression of Eng+/+ and Eng-/- MEECs in response to TGF-β treatment over 24 h period. (D) Comparison of ERK activation and c-Myc expression in Eng-/- MEECs expressing no endoglin (control), WT endoglin, or endoglin point mutant unable to bind β-arrestin2 (T650A).