Table 1.

Comparison of Normal-Weight Controls and Adolescent Girls with Anorexia Nervosa

	Controls (n=25)	Anorexia Nervosa (n=44)	p (Controls vs. AN)
Age (y)	15. 7±0. 23	16. 7±0. 22	0. 006
Bone age (y)	15. 7±0. 25	16. 2±0. 17	NS
Weight (kg)	57. 2±1. 4	46. 7±0. 8	<0. 0001
BMI (kg/m2)	21. 11±0. 55	17. 2±0. 21	<0. 0001
Tanner stage (breasts)	4. 66±0. 09	4. 59±0. 10	NS
Amenorrhea duration (y)	-	0. 935±0. 123	-
Exercise Activity (h)	16. 2±2. 2	17. 0±1. 9	NS
Calcium intake (mg)	1096±102	2055±139	<0. 0001
Vitamin D intake (IU)	174±31	570±42	<0. 0001
DXA Measures
Fat mass (kg)	15. 1±0. 8	8. 8±0. 4	<0. 0001
Lean mass (kg)	41. 78±0. 81	37. 31±0. 69	0. 0003
Lumbar BMD (g/cm2)	0. 944±0. 014	0. 833±0. 010	<0. 0001
Lumbar BMD Z-score	−0. 14±0. 11	−1. 37±0. 09	<0. 0001
Biochemical Parameters
25(OH) vitamin D (ng/ml)	22. 2±1. 1	30. 2±1. 4	<0. 0001
PTH (pg/ml)	9. 6±2. 1	21. 3±2. 0	<0. 0001
Estradiol (pg/ml)	43. 1±2. 0	29. 3±2. 4	<0. 0001
24-hr UFC (mcg)	38. 7±2. 3	65. 1±6. 6	0. 003
IGF-1 (ng/ml)	366±20	227±13	<0. 0001
Leptin (ng/ml)	11. 2±1. 1	5. 0±0. 6	<0. 0001
P1NP (ng/ml)	194. 8±23. 6	97. 2±11. 2	<0. 0001
CTX (ng/ml)	1. 04±0. 07	0. 73±0. 06	0. 002
Sclerostin (ng/ml)	0. 408±0. 018	0. 422±0. 016	0. 70

NS: not significant