Effects of control (vehicle, VEH) or stress hormones, norepinephrine (NE), epinephrine (EPI), corticosterone (CORT), NE+EPI, NE+CORT, EPI+CORT, and NE+EPI+CORT (bars shown in this order) on CD62L− and CD62L+ monocyte and neutrophil numbers and CD62L expression on monocytes and neutrophils. Leukocyte numbers (1000 /μl blood) were quantified 2 hours after vehicle or hormone injection in adrenalectomized animals. CD62L surface expression is expressed as mean fluorescence intensity (MFI) as measured on the flow cytometer. An increase in immune cell numbers relative to the VEH group represents mobilization of leukocytes into the blood. A decrease represents trafficking of cells out of the blood and into tissues. Data are expressed as means ± SEM (n=3 or 4 per treatment group). Statistically significant differences are indicated: * p < 0.05, and ** p < 0.01: relative to baseline (Fisher's LSD); † p < 0.05, and †† p < 0.01: please see text for selected comparison groups (Fisher's LSD).