Table 2.
Values of the apparent dissociation constant Kd and calculated apparent free energy of binding, ΔG. The tabulated values were obtained from fluorescence anisotropy data and Equations 1 and 2. Standard error for each value of ΔG was 0.1 kcal/mol.
| Peptides | Kd (μM) (for 30% PG SUV) | ΔG (kcal/mol) |
|---|---|---|
| S4-W | 174 ± 28 | −5.1 |
| W-S4 | 132 ± 21 | −5.3 |
| S4(F9W, W18F) | 73 ± 13 | −5.6 |
| S4-W(R10−1) | 279 ± 32 | −4.9 |
| S4-W(R10−2) | 496 ± 51 | −4.5 |
| S4-W(R7,10−2) | 286 ± 41 | −4.8 |
| S4-W(R4,7,10−2) | 241 ± 35 | −4.9 |
| S4-W(R4,7,10,13−2) | 234 ± 39 | −4.9 |
| S4-W(Rregain−2) | 172 ± 22 | −5.1 |
| S4-W (F9P) | 696 ± 122 | −4.3 |