Table I. SRM determined protein fold change versus time matched vehicle control after drug treatment. Protein fold change is reported as the ratio among drug treatment groups of median summed peptide abundances; HK, housekeeping protein (control); PX, proteomics label-free LC-MS; GX, gene expression (transcriptomics); LIT, literature source; Veh/Veh indicates the fold change of the day 15 vehicle over the day 4 vehicle animals where no (drug induced) effect is expected; bold font indicates 0.5 > fold change > 2.0; T-test p values are indicated by *<0.05, **<0.01, ***<0.001.

Uniprot acc.	Protein	Source	Peptides	Low dose		High dose		Veh/Veh
				Day 4	Day 15	Day 4	Day 15
O35077	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	HK	1	1.15	1.05	1.17	1.26	0.98
P04642	l-lactate dehydrogenase A chain	HK	3	0.92	0.9	1.18	1.01	0.92
P10719	ATP synthase subunit beta, mitochondrial	HK	5	1.02	1.08	1.01	1.02	0.89
P15999	ATP synthase subunit alpha, mitochondrial	HK	5	1.08	1.08	1	0.82	0.76
P85108	Tubulin beta-2A chain	HK	1	1.15	0.97	0.88	0.9	0.86
P05178	Cytochrome P450 2C6	PX	3	1.06	1.59**	3.43***	6.28***	0.65*
P23965	3,2-trans-enoyl-CoA isomerase, mitochondrial	PX	1	1.18	1.45	6.37***	10.46***	1
Q4V8F9	Hydroxysteroid dehydrogenase-like protein 2	PX	1	0.85	1.02	4.11***	2.93***	1.44
Q64591	2,4-dienoyl-CoA reductase, mitochondrial	PX	2	1.07	1.33*	2.95***	6.21**	1.01
O88267	Acyl-coenzyme A thioesterase 1	PX + GX	1	0.71	0.31	1188.27***	690.64**	1.18
P04903	Glutathione S-transferase alpha-2	PX + GX	1	0.99	1.18	2.81***	5.96***	0.89
P07687	Epoxide hydrolase 1	PX + GX	3	0.98	1.16	2.86***	6.07***	0.72
P07896	Peroxisomal bifunctional enzyme	PX + GX	4	1.19	1.36	17.23***	10.13***	0.72
P08516	Cytochrome P450 4A10	PX + GX	2	1.01	1.3	19.49***	13.89***	0.85
P09875	UDP-glucuronyltransferase 2B1	PX + GX	1	1.08	0.82	1.23*	1.64**	1.19
P14141	Carbonic anhydrase 3	PX + GX	5	1.01	1.09	0.66*	0.5***	0.73
P21775	3-ketoacyl-CoA thiolase A, peroxisomal	PX + GX	4	1.03	1.07	7.88***	7.22***	0.85
P38918	Aflatoxin B1 aldehyde reductase member 3	PX + GX	1	1.24	0.86	3.64***	6.77**	0.79
P51647	Retinal dehydrogenase 1	PX + GX	2	1.66	2.06	13.19***	34.41***	0.7
Q6I7R1	Dehydrogenase/reductase (SDR family) member 7	PX + GX	2	1.08	0.82	0.81	0.36**	0.98
O55171	Acyl-coenzyme A thioesterase 2, mitochondrial	GX	1	1.1	1.02	4.87***	4.91**	0.94
P00176	Cytochrome P450 2B1	GX	1	1.35	1.22*	54.5***	26.37**	0.95
P04182	Ornithine aminotransferase, mitochondrial	GX	2	0.91	1.29	0.21***	0.42**	0.87
P04906	Glutathione S-transferase P	GX	1	1.01	1.11	0.93	1.81	0.98
P05369	Farnesyl pyrophphate synthase	GX	1	0.84	1.18	0.63	1.97*	0.93
P06757	Alcohol dehydrogenase 1	GX	3	1.21	1.21	1.21	1.94**	0.71
P13697	NADP-dependent malic enzyme	GX	2	1.38	0.88	1.92**	6.62**	1.15
P36365	Dimethylaniline monooxygenase [N-oxide-forming] 1	GX	1	0.96	0.94	0.63	0.47	0.53
Q5XI60	Receptor expression-enhancing protein 6	GX	1	0.87	0.9	1.72***	2.7***	0.86
Q64654	Lanterol 14-alpha demethylase	GX	1	0.87	0.94	0.84	1.53*	0.78
Q6TEK3	Vitamin K epoxide reductase complex subunit 1-like protein 1	GX	1	1.06	1.14	1.28	1.43*	0.93
Q9EQ76	Dimethylaniline monooxygenase [N-oxide-forming] 3	GX	5	1.06	1.12	0.81	0.39***	1.15
B4F7D0	Prodh protein (Fragment)	GX	1	0.75	1.13	0.59	0.76	0.89
Q5XFW5	FK506 binding protein 11	GX	1	0.99	0.97	1.29*	1.93*	0.8*
P01048	T-kininogen 1	LIT [30]	1	1.14	0.93	1.33	1.21	1.08
P55159	Serum paraoxonase/arylesterase 1	LIT [30]	2	1.13	1.11	1.55**	1.38	1.09
O89049	Thioredoxin reductase 1, cytoplasmic	LIT [11]	2	1.02	1.04	1.61**	1.96***	0.94
P04041	Glutathione peroxidase 1	LIT [11]	4	1.2	0.94	1.14	0.66*	1.02
P04762	Catalase	LIT [11]	5	1.08	1.17	1.12	1.25	0.81*
P04785	Protein disulfide-isomerase	LIT [11]	3	0.98	1.01	0.92	1.42**	0.89
P06761	78 kDa glucose-regulated protein	LIT [11]	3	0.98	0.93*	1.08	1.54***	0.85
P07632	Superoxide dismutase [Cu-Zn]	LIT [11]	3	0.98	1.01	0.96	1.03	0.88
P07895	Superoxide dismutase [Mn], mitochondrial	LIT [11]	2	0.97	1	0.9	1.12	0.97
P14480	Fibrinogen beta chain	LIT [11]	3	1.03	0.78	0.89	1.19	1.16
P18418	Calreticulin	LIT [11]	1	1.01	0.99	0.99	1.36**	0.88
P35565	Calnexin	LIT [11]	2	0.99	1.04	0.98	1.13	0.94*
P48199	C-reactive protein	LIT [11]	2	0.81	0.68	1.21	1.03	1.05
P31044	Phphatidylethanolamine-binding protein 1	LIT [7]	2	1.05	0.96	0.9*	0.89	0.87*