Table 2.

Power of score analysis to detect association using different datasets and weighting factors using variant counts generated from those observed in NOD28

Variants used	MAF		Power to achieve target P-value				Mean −log(p)
	Controls	Cases	P < 0.001	P < 0.0001	P < 0.00001	P < 0.000001
Common variants
5′ UTR-33 G→T	0.330	0.419	0.21	0.08	0.02	0.01	2.19
534 C→G	0.383	0.309	0	0	0	0	0.04
802 C→T	0.277	0.414	0.73	0.48	0.28	0.12	4.09
1377 C→T	0.286	0.418	0.67	0.41	0.20	0.09	3.80
1761 T→G	0.403	0.332	0	0	0	0	0.05
2104 C→T	0.044	0.108	0.39	0.11	0.01	0	2.76
2722 G→C	0.010	0.061	0.47	0.06	0	0	2.94
2863 G→A	0.102	0.070	0	0	0	0	0.08
3020insC	0.019	0.106	0.92	0.62	0.25	0.06	4.36
Nine common variants			0.86	0.65	0.43	0.25	4.84
53 rare variants			0.20	0.04	0	0	2.20
Combined, f = 1			0.94	0.83	0.64	0.42	5.78
Combined, f = 10			0.98	0.91	0.77	0.57	6.37
Combined, f = 100			0.96	0.85	0.67	0.44	5.77
Combined, f = 1000			0.96	0.84	0.65	0.41	5.69

Note: Sample size consists of 453 cases and 103 controls.

Abbreviations: MAF, minor allele frequency; f, weighting factor.