Table 1.
Mean (±SD) pK parameters for mesalamine following single dose and steady state administration of MMX mesalamine under fasting or postprandial status
| Dosage | N | Cmax (ng/mL) | Median Tmax (hours) | AUC0–∞ (ng h mL) | t½ (hours) |
|---|---|---|---|---|---|
| 2.4 g40,a | 48 | 1595 (±1484) | 12 (4–31) | 21,084 (±13185) | 7.05 (±5.54) |
| 4.8 g40,a | 48 | 2154 (±1140) | 12 (4–34) | 44775 (±30,302) | 7.25 (±8.32) |
| 2.4 g42,b | 37 | 1553c (857–2812) | 13,556c (7616–24,128) | 10.2c (5.8–19.9) |
Notes:
a
single dose administration (fasting);
b
steady state administration (postprandial);
c
square geometric means (95% confidence intervals).
Abbreviations: SD, standard deviation; AUC, area under the plasma concentrationtime curve; Cmax, maximum plasma concentration; t½, elimination half-life; Tmax, time to Cmax.