Figure 1.

Morphine treatment exacerbates renal pathology in NY1DD mice. H&E stained kidney sections of NY1DD mice treated with morphine for 3 weeks. Cortical and cortico-medullary regions with glomerular and tubular histology are shown. Glomerular and tubular morphology in PBS-treated mouse kidneys (A and B). Note the severe intraglomerular congestion (C and E, black arrows), tubular dilatation and loss of brush border (D, green arrow), and peritubular congestion (black arrow) in morphine-treated mice.

Notes: Magnification (A–D): ×400; scale bar, 125 μM. E, ×1000; scale bar, 50 μM. Each photomicrograph is representative of kidney tissue from 6 mice each.

Abbreviations: H&E, hematoxylin and eosin; MS, morphine sulfate, PBS, phosphatebuffered saline.