Figure 5.

Morphine treatment increases glomerular volume. (A–C) Glomerular volume of NY1DD (A), hBERK1 (B), and BERK (C) mice treated with morphine and/or naloxone for 3 or 6 weeks as indicated. Note that morphine stimulates a significant increase in glomerular volume, which is abrogated by co-treatment with naloxone, although naloxone alone did not alter glomerular volume.

Notes: Each bar represents the mean ± SD of 3–6 mice/group; equal numbers of male and female mice were used except in one group (1 male and 2 females).

Abbreviations: MS, morphine sulfate; Nal, naloxone; PBS, phosphate-buffered saline; SD, standard deviation.