Table 3.
ADRs during hospital stay, grouped according to the System Organ Classification of WHO-ART, and related drugs
| ADRs | Drug classes* |
|---|---|
| Metabolic and nutritional disorders (110) | |
| Hypokalemia (75) | Diuretics (73); antithrombotic agents (8); Potassium-sparing diuretics (3); cardiac glycosides (3) |
| Hyponatremia (17) | Potassium-sparing diuretics (12); diuretics (6); antiulcer agents (4) |
| Hyperglycemia (13) | Corticosteroids (13) |
| Hyperkalemia (12) | Potassium-sparing diuretics (8); corticosteroids (2); antiulcer agents (2); antithrombotic agents (2); angiotensin-2 receptor antagonists (2) |
| Gastrointestinal system disorders (34) | |
| Diarrhea (15) | Antibacterials (14); antithrombotic agents (2) |
| Constipation (10) | Analgesics and antipyretics (6); opioids (4) |
| Platelet, bleeding and clotting disorders (31) | |
| INR increase (15) | Antithrombotic agents (15); diuretics (3) |
| Thrombocytopenia (13) | Antithrombotic agents (13); diuretics (2) |
| Skin and appendages disorders (31) | |
| Rash erythematosus (15) | Antibacterials (14); antithrombotic agents (2); diuretics (2) |
| Urticaria (5) | Antibacterials (2) |
| Hyperhidrosis (2) | Opioids (2) |
| Application site disorders (20) | |
| Hematoma at the injection site (18) | Antithrombotic agents (17); analgesic/antipyretics (2); NSAIDs (2) |
| Red blood cell disorders (19) | |
| Anemia (19) | Antithrombotic agents (17); analgesics and antipyretics (8); diuretics (3) |
Notes: Groups of ADRs that occurred in at least 10 patients are shown.
*
Drug classes suspected in at least 2 patients are listed. Figures in parentheses indicate the number of patients.
Abbreviations: ADRs, adverse drug reactions; INR, international normalized ratio; NSAIDs, nonsteroidal anti-inflammatory drugs; WHO-ART, World Health Organization Adverse Reaction Terminology.