Table 2: GRADE Quality of Studies – Morbid Obesity.

Outcome	Design	Quality	Consistency	Directness	Overall Quality
Weight Loss	RCT “O-01 Trial” According to Shikora (2004), considered “update of ongoing clinical trials”. Case series	Low Why? No sample size calculation. Small sample size. No ITT analysis. Lack of detail regarding dropouts. Possible Type 2 error. Sparse details about randomization/blinding. Full, final results not published. Same as above.	Some uncertainty. Why? Only 1 RCT (technically grey literature).	Generally direct (%EWL).	Very Low
Resolution of Comorbidities	Case series	Same as above	? Scanty data	? Scanty data	Very Low