Hox4 and Hox5 paralogous group (PG) genes are expressed in the presumptive forelimb region of the LPM. (A-G) Tbx5 is expressed in the LPM of the E8 (7- to 9-somite) mouse embryo (A). PG4 and PG5 Hox genes are co-expressed in this domain: Hoxa4 (B), Hoxb4 (C), Hoxc4 (D), Hoxa5 (E), Hoxb5 (F) and Hoxc5 (G). The arrowhead marks the level of somite 3 in each embryo. (H) Fifteen-somite embryo showing endogenous expression of Tbx5. (I-N) Expression of Hoxa4 (I), Hoxb4 (J), Hoxc4 (K) and Hoxa5 (L) at the 14-somite stage and of Hoxb5 (M) and Hoxc5 (N) at the 13-somite stage. Embryos in A-G are dorsal views, anterior to the top, whereas H-N are lateral views of the right side with anterior to the top.