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Model for the activation of Tbx5 in the LPM. Hox genes belonging to PG4 and PG5 are expressed in the presumptive forelimb LPM where they bind to the intron 2 early forelimb enhancer of the mouse Tbx5 gene to specifically activate its transcription and allow Tbx5-mediated initiation of forelimb outgrowth. ex1, exon1; ex2, exon2; LPM, lateral plate mesoderm; NT, neural tube; som, somites.
