Table 4.

Cumulative Incidence of Toxicity by End of Chemotherapy

Key Toxicity	Grade 3 or 4			Grade 4 Only
	CV	TPCV	P	CV	TPCV	P
Absolute neutrophil count	94	77	< .001	73	48	< .001
Platelets	21	48	< .001	8	26	< .001
Hemoglobin	35	40	.91	6.1	7.9	.68
ALT	3	11	.004	1.2	2.8	.09
Total bilirubin	0.0	1.5	.16	0.0	0.7	.32
Creatinine	1.2	0.0	1.00	1.2	0.0	1.00
Creatinine clearance	0.0	0.9	.33	0.0	0.0	1.00
Pulmonary	2.1	3.3	.44	1.0	2.6	.34
Calcium	4.8	2.5	.69	2.9	1.7	.64
Magnesium	2.8	2.3	.65	0.7	0.0	.32
Peripheral nervous system	19	19	.92	0.0	0.0	1.00
CNS	12	24	.004	0.7	3.4	.19
Allergy	10	0	< .001	2.8	0.0	.08
Infection	23	26	.39	0.0	1.7	.16

Abbreviations: CV, carboplatin and vincristine; TPCV, thioguanine, procarbazine, lomustine, and vincristine.