Table 5.
Homology modeling programs used in drug design.
| Name | Developed by | Incorporated into software package | Free for academia | Drug design applications | Ref. |
|---|---|---|---|---|---|
| ICM | Molsoft LLC | Molsoft | No | Aryl hydrocarbon receptor ligands G-protein coupled receptor antagonists |
[126] [141] |
| Modeller | University of California, San Francisco† | Discovery Studio | Yes | Inhibitors of penicillin-binding protein Cdc25 phosphatase inhibitors G-protein coupled receptor antagonists |
[115] [142] [143] |
| MOE | Chemical Computing Group | MOE | No | Inhibitors of Jumonji domain-containing protein histone demethylases Inhibitors of human glutaminyl cyclase |
[144] [145] |
| Prime | Schrödinger, Inc. | Schrödinger | No | Janus kinase 3 inhibitors Inhibitors of the mammalian target of rapamycin kinase |
[146] [147] |
| SWISS-MODEL | Swiss Institute of Bioinformatics‡ | Yes | Inhibitors of osteoclast formation and bone resorption | [114] |