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. 2012 Aug 6;198(3):439–456. doi: 10.1083/jcb.201111012

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© 2012 Reed et al.

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Figure 10. — Model of the association of PBPs with Gag during immature HIV-1 capsid assembly. Newly synthesized Gag forms the ∼10S AI, a possible source of targeted Gag at the PM, which may be recruited for oligomerization at sites of assembly (dotted lines). Gag co-opts a complex of ABCE1 and PBPs, present in uninfected cells, to form the ∼80S AI. Analysis of G2A Gag mutants suggests that the ∼80S AI or the ∼150S AI targets Gag to the PM (dotted line). Gag continues to multimerize at the PM, forming the ∼500S AI, which also contains ABCE1 and PBPs. DDX6 facilitates multimerization of Gag at the PM. Upon formation of completed capsids (∼750S), PBPs and ABCE1 are released, and budding occurs.