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. 2012 Aug 6;198(3):331–341. doi: 10.1083/jcb.201204086

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© 2012 Bellis et al.

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Figure 3. — The LOBA/OCD unit generates anisotropic daughter cell movement that is lost in Apc^Min/+ crypts. Dotted lines delineate the original cell position relative to the daughters. (A) In wt crypts exhibiting LOBA, mitotic cells maintain a BP (dotted stalk) uniformly bent toward the crypt bottom. Whenever a dividing cell exhibits longitudinal spindle orientation (80% of the cases), only the daughter closest to the crypt base inherits the BP, whereas the other moves one position upwards (black arrow). (B) In LOBA⁻ Apc^Min/+ crypts, the BP is positioned centrally such that both daughters inherit it, abolishing anisotropic movement (black arrows). Bars: (A and B, first row) 10 µm; (A and B, bottom images) 5 µm. Red lines indicate the spindle axis.