Figure 7. Simulated centripetal (A) and centrifugal (B) motion-induced changes in the membrane potential (ΔV_m) of SAC dendritic tips (Z) as a function of ΔE_GA (X), the proximal–distal dendritic difference in E_GA, and the delay in GABA channel closing (Y).

A, the amplitude of the depolarizing response calculated in the centripetal dendritic tip was little affected when only the delay in GABA channel closing was increased or when only ΔE_GA was increased. However, the centripetal response was dramatically reduced when both the delay in GABA channel closing and ΔE_GA were increased. B, the amplitude of the depolarizing response calculated in the centrifugal dendritic tip was not altered by increasing the delay in GABA channel closing and/or the size of ΔE_GA. ΔV_m is the response relative to the resting membrane potential.