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. Author manuscript; available in PMC: 2012 Aug 8.
Published in final edited form as: Expert Opin Pharmacother. 2011 Feb;12(2):285–292. doi: 10.1517/14656566.2011.543129

Figure 2.

Figure 2

Nod2 is an intracellular MDP sensor. Monocytes/macrophages activation by L-MTP-PE is mediated via Nod2. L-MTP-PE is selectively phagocyted by monocytes and macrophages after intravenous administration. L-MTP-PE is released into the cytosol and degraded to MDP. Nod2 binding to MDP activates NF-κB and influences the innate immune response. Abbreviations: Nod2; nucleotide-binding oligomerization domain 2, MDP; muramyl dipeptide, L-MTP-PE; liposomal muramyl tripeptide phosphatidyl ethanolamine, NF-κB; nuclear factor-kappa B.