Table 4. Tests for Compositional Epistasis Under Model (3).

Monotonicity Assumption	Condition on Model (3)	Form of Epistasis
G1 and G2 Monotonic	γint>0	Table 1a
	γint> (α†27−α†1)+(β†2−β†1)	Table 1d
	γint> (β†1−α†1)	Table 2a
	γint> (α†1−β†1)	Table 2b
G1 Monotonic	γint> log(2)/4	Table 2c
G2 Monotonic	γint> log(2)/4	Table 2d
G1 or G2 Monotonic	γint> log(3)	Table 1a
No Assumption	γint> log(4)/4	Table 2c and 2d
	γint> log(8)	Table 1a