Table 2. Summary of statistically significant biofunctions associated with the molecules that are differently regulated in Mmp13−/− granulation tissues at day 7 compared to the corresponding WT samples (IPA Functional Analysis).1 .
| Category 2 | Function Annotation | p-value 3 | Number of Molecules | Regulation z-score 4 |
| Cellular Growth and Proliferation | proliferation of cells | 2.19E-13 | 71 | 1.266 |
| growth of fibroblast cell lines | 8.86E-04 | 9 | −1.463 | |
| proliferation of smooth muscle cells | 1.50E-03 | 8 | 1.160 | |
| Cellular Movement | migration of cells | 8.01E-12 | 51 | −0.369 |
| leukocyte migration | 6.48E-08 | 28 | 0.204 | |
| migration of endothelial cells | 4.86E-07 | 13 | 1.226 | |
| chemotaxis | 1.11E-06 | 19 | 0.929 | |
| Inflammatory Response | immune response | 3.55E-11 | 45 | 1.207 |
| inflammatory response | 1.55E-09 | 26 | −0.008 | |
| activation of leukocytes | 1.96E-07 | 22 | 0.392 | |
| Cell Death | cell death | 4.78E-10 | 75 | −0.671 |
| apoptosis | 1.55E-06 | 54 | −1.579 | |
| cell death of immune cells | 4.42E-06 | 21 | 1.015 | |
| cell death of connective tissue cells | 3.69E-05 | 19 | −0.731 | |
| cell death of endothelial cells | 5.80E-05 | 8 | −0.904 | |
| neuronal cell death | 5.86E-05 | 19 | −2.707 | |
| 5 Others | neoplasia | 1.54E-11 | 82 | 2.574 |
| rheumatic disease | 1.62E-08 | 49 | −0.104 | |
| arthritis | 8.00E-08 | 46 | 0.203 | |
| adhesion of connective tissue cells | 6.18E-07 | 10 | 0.195 | |
| differentiation of connective tissue cells | 3.83E-06 | 18 | −0.400 | |
| vasculogenesis | 4.90E-06 | 20 | 1.897 |
1
The threshold with FC>0.5 and p<0.05 was used to determine differentially expressed molecules.
2
Category of related biofunctions.
3
The probability that the association between a set of genes in the dataset and a related function is due to random association.
4
The z-score predicts the direction of change for the function. A positive z-score indicates increased function and negative z-score indicates reduced function. An absolute z-score of ≥2 is considered significant.
5
Others includes categories: Cancer, Tissue Development, Cellular Development, Cardiovascular System Development and Function, Skeletal and Muscular Disorders.