Table 4. Summary of statistically significant biofunctions associated with the molecules that are differently regulated in Mmp13−/− granulation tissues at day 21 compared to the corresponding WT samples (IPA Functional Analysis).1 .
| Category 2 | Function Annotation | p-value 3 | Number of Molecules | Regulation z-score 4 |
| Cellular Movement | migration of endothelial cells | 1.84E-10 | 19 | −1.063 |
| cell movement of tumor cell lines | 2.90E-10 | 32 | 2.917 | |
| cell movement of muscle cells | 1.63E-09 | 15 | 1.541 | |
| migration of fibroblast cell lines | 4.07E-09 | 12 | 1.583 | |
| migration of vascular smooth muscle cells | 3.47E-05 | 7 | 2.088 | |
| Cell Death | apoptosis | 1.01E-14 | 87 | −3.191 |
| apoptosis of tumor cell lines | 4.55E-10 | 44 | −2.779 | |
| cell survival | 4.86E-08 | 42 | 2.21 | |
| neuronal cell death | 1.37E-05 | 24 | −1.351 | |
| cell death of connective tissue cells | 2.35E-05 | 23 | −2.141 | |
| apoptosis of muscle cells | 6.28E-04 | 10 | −1.709 | |
| Cellular Growth and Proliferation | proliferation of cells | 6.58E-15 | 89 | 2.986 |
| proliferation of connective tissue cells | 3.06E-09 | 24 | 2.694 | |
| proliferation of tumor cell lines | 3.12E-07 | 33 | 2.611 | |
| proliferation of endothelial cells | 4.25E-07 | 14 | −0.488 | |
| proliferation of epithelial cells | 4.41E-06 | 17 | 3.133 | |
| Inflammatory Response | immune response | 6.01E-12 | 55 | 0.896 |
| inflammatory response | 8.92E-09 | 29 | 1.506 | |
| cell movement of phagocytes | 2.74E-08 | 25 | 0.839 | |
| chemotaxis of phagocytes | 5.06E-06 | 14 | 2.594 | |
| chemotaxis of monocytes | 9.84E-05 | 7 | 2.886 | |
| Cellular Development | differentiation | 8.72E-12 | 67 | 1.133 |
| endothelial cell development | 3.27E-10 | 19 | −0.225 | |
| differentiation of connective tissue cells | 1.88E-08 | 25 | 0.905 | |
| Others 5 | tumorigenesis | 1.27E-24 | 134 | −0.432 |
| angiogenesis | 5.37E-11 | 31 | −0.753 | |
| development of organ | 1.21E-10 | 60 | 0.929 | |
| arthritis | 3.86E-09 | 59 | −0.643 | |
| vascularization | 1.06E-08 | 15 | 1.323 | |
| cellular homeostasis | 3.65E-07 | 41 | 3.366 | |
| lymphangiogenesis | 2.54E-06 | 6 | n.c. |
1
The threshold with FC>0.5 and p<0.05 was used to determine differentially expressed molecules.
2
Category of related biofunctions.
3
The probability that the association between a set of genes in the dataset and a related function is due to random association.
4
The z-score predicts the direction of change for the function. A positive z-score indicates increased function and negative z-score indicates reduced function. An absolute z-score of ≥2 is considered significant. n.c., not calculated.
5
Others includes categories: Cancer, Cellular Function and Maintenance, Tissue Development, Connective Tissue Disorders, Organismal Development, Cardiovascular System Development and Function.