Table 1. Multivariate Cox regression including the 40-gene test and breast cancer clinical variables.

Variable		HR1	95% CI2	p-val
40-gene test	H vs L	4.43	2.46 to 7.95	8.5×10−8 *
	I vs L	2.06	1.13 to 3.74	6.7×10−7 *
tumor size (T2 vs T1)		2.21	1.52 to 3.21	3.0×10−5 *
Node (positive vs negative)		1.07	0.78 to 1.46	0.69
ER status (negative vs positive)		1.15	0.77 to 1.72	0.50
Grade (3 vs 1 and 2)		1.00	0.72 to 1.41	0.98
Age (≤50 vs >50, years)		1.27	0.82 to 1.97	0.28

Total number of samples is 668. Endpoint analyzed was distant metastasis at 10 years.

Cox analysis was done stratifying by dataset.

¹HR: Hazard ratio.

²CI: confidence interval.

^*Significant p-values.