Table 2. Top 10 pertubagens identified through the Connectivity Map that induce a reverse 682-signature.
Rank1 | Perturbagen - cell line | Mean2 | Description | p-val3 |
1 | trichostatin A - PC3 | −0.676 | HDAC inhibitor | 0 |
2 | trichostatin A - MCF7 | −0.600 | HDAC inhibitor | 0 |
3 | vorinostat - MCF7 | −0.708 | HDAC inhibitor | 0.00006 |
5 | 0175029-0000 - PC3 | −0.763 | nd | 0.00048 |
6 | sirolimus - MCF7 | −0.389 | mTOR inhibitor | 0.00066 |
7 | ellipticine - MCF7 | −0.848 | Topoisomerase IIinhibitor | 0.0007 |
8 | LY-294002- MCF7 | −0.499 | PIK3CA inhibitor | 0.00084 |
9 | thioridazine - PC3 | −0.695 | Dopamine receptor inhibitor | 0.00118 |
15 | harmine - MCF7 | −0.842 | Monoamine oxidase inhibitor | 0.00233 |
16 | tomatidine - MCF7 | −0.830 | ACAT1 inhibitor | 0.00243 |
Ranking based upon permutation analysis of the same perturbagen made in the same cell line.
Arithmetic mean of the connectivity scores.
An estimate of the likelihood that the enrichment of a set of instances in the list of all instances in a given result would be observed by chance.