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. 2012 Aug 7;7(8):e42494. doi: 10.1371/journal.pone.0042494

Table 2. Top 10 pertubagens identified through the Connectivity Map that induce a reverse 682-signature.

Rank1 Perturbagen - cell line Mean2 Description p-val3
1 trichostatin A - PC3 −0.676 HDAC inhibitor 0
2 trichostatin A - MCF7 −0.600 HDAC inhibitor 0
3 vorinostat - MCF7 −0.708 HDAC inhibitor 0.00006
5 0175029-0000 - PC3 −0.763 nd 0.00048
6 sirolimus - MCF7 −0.389 mTOR inhibitor 0.00066
7 ellipticine - MCF7 −0.848 Topoisomerase IIinhibitor 0.0007
8 LY-294002- MCF7 −0.499 PIK3CA inhibitor 0.00084
9 thioridazine - PC3 −0.695 Dopamine receptor inhibitor 0.00118
15 harmine - MCF7 −0.842 Monoamine oxidase inhibitor 0.00233
16 tomatidine - MCF7 −0.830 ACAT1 inhibitor 0.00243
1

Ranking based upon permutation analysis of the same perturbagen made in the same cell line.

2

Arithmetic mean of the connectivity scores.

3

An estimate of the likelihood that the enrichment of a set of instances in the list of all instances in a given result would be observed by chance.