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. 2012 Aug 7;7(8):e42351. doi: 10.1371/journal.pone.0042351

Table 1. Resistant β-tubulin mutations selected for computational study.

Mutation Cell Type Phenotype Reference
T274I Human Decreased MT stabilization, epothilone resistant, reduced sensitivity to taxol 20–22
R282Q Human Decreased MT stabilization, epothilone resistant, reduced sensitivity to taxol 21,22
Q292E Human Decreased MT stabilization, epothilone resistant, reduced sensitivity to taxol 22–24